Sequencing Center

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Scientists&Research

Sequencing Center

Tao Cai, Ph.D.

Director of Sequencing Center, NIBS, Beijing, China

Phone：010-80726688-8880

Room Number: B027

E-mail: caitao@nibs.ac.cn

Sequencing Center

Sequencing technology has developed rapidly in recent years. New sequencing technologies which widely used in genomics, transcriptomics and epigenetics can provide vast amounts of information. It also facilitate in Model Organism and tumor biology research. Sequencing Center has ABI 3730xl DNA analyzer and Illumina Genome Analyzer IIx, by which it can provide services including the traditional Sanger sequencing, high-throughput sequencing and follow-up analysis of high-throughput sequencing data. By using sequencing techniques, sequencing center will collaborate with other labs do their best to solve specific biological problems and expand the application field of sequencing technology.

Publications

1. T. Cai, J.F. Dufour, B. Muellhaupt, T. Gerlach, M. Heim, D. Moradpour, A. Cerny, R. Malinverni, V. Kaddai, M. Bochud, et al., Viral Genotype-Specific Role of PNPLA3, PPARG, MTTP and IL28B in Hepatitis C Virus-Associated Steatosis. J Hepatol, 2011.

2. Rauch, A., Z. Kutalik, P. Descombes, T. Cai, J. Di Iulio, T. Mueller, M. Bochud, M. Battegay, E. Bernasconi, J. Borovicka, et al., Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology, 2010. 138(4): p. 1338-45, 1345 e1-7.

3. Wei, B.*, T. Cai*, R. Zhang*, A. Li, N. Huo, S. Li, Y.Q. Gu, J. Vogel, J. Jia, Y. Qi, et al., Novel microRNAs uncovered by deep sequencing of small RNA transcriptomes in bread wheat (Triticum aestivum L.) and Brachypodium distachyon (L.) Beauv. Funct Integr Genomics, 2009. * co-first authors

4. Bochud, P.Y., T. Cai, K. Overbeck, M. Bochud, J.F. Dufour, B. Mullhaupt, J. Borovicka, M. Heim, D. Moradpour, A. Cerny, et al., Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C. J Hepatol, 2009.51(4): p. 655-66.

5. Mi, S.*, T. Cai*, Y. Hu, Y. Chen, E. Hodges, F. Ni, L. Wu, S. Li, H. Zhou, C. Long, et al., Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide.Cell, 2008. 133(1): p. 116-27. * co-first authors

6. Wu, J., X. Mao, T. Cai, J. Luo, and L. Wei, KOBAS server: a web-based platform for automated annotation and pathway identification. Nucleic Acids Res, 2006. 34(Web Server issue): p. W720-4.

7. T. Cai, X. Mao, S. Li, and L. Wei, Genome comparison using Gene Ontology (GO) with statistical testing. BMC Bioinformatics, 2006. 7: p. 374.

8. Mao, X.*, T. Cai*, J.G. Olyarchuk, and L. Wei, Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary. Bioinformatics, 2005. 21(19): p. 3787-93. * co-first authors

9. Yu, Z., T. Li, T. Cai, J. Zhao, and J. Luo, [MGAP-A microbe genome annotation platform]. Wei Sheng Wu Xue Bao, 2003. 43(6): p. 805-8.

10. Chen, Y.J., G. Gao, Y.M. Bao, R. Lopez, J.M. Wu, T. Cai, Z.Q. Ye, X.C. Gu, and J.C. Luo, [Initial analysis of complete genome sequences of SARS coronavirus]. Yi Chuan Xue Bao, 2003. 30(6): p. 493-500.

11.Tao, W., C.H. Yan, T. Cai, S. Hao, and Z.H. Zhai, Structural components of the nuclear body in nuclei of Allium cepa cells. Cell Res, 2001. 11(1): p. 68-73.