Information
Qi Li,Ph.D.
Director of Genetic Screening Center, NIBS, Beijing, China
Phone：010-80726688-8677
E-mail:wangyibing@nibs.ac.cn

11/2017-present: Postdoc, National Institute of Biological Science

FunctionGenetic Screening Center:
Adeno-associated virus (AAV) is currently one of the most widely used gene delivery tools in both scientific research and gene therapy. AAV has many advantages, including low immunogenicity, low genomic integration, high transduction rate, and stable and persistent expression. The Genetic Screening Center provides AAV technical services including vector construction, packaging, purification, titration and functional test for different labs. The Genetic Screening Center provides multiple common serotypes of recombinant Adeno-associated virus and helps construct AAVs for either expression or knockout of target genes. Moreover, the center is committed to develop and evolve new serotype vectors according to different labs’ demand and interest.

Publications:

1. Cao, Y., J. Zheng, H. Wan, Y. Sun, S. Fu, S. Liu, B. He, G. Cai, Y. Cao, H. Huang, Q. Li, Y. Ma, S. Chen, F. Wang and H. Jiang (2023). "A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease." EMBO J 42(13): e113033.

2. He, B., H. Yu, S. Liu, H. Wan, S. Fu, S. Liu, J. Yang, Z. Zhang, H. Huang, Q. Li, F. Wang, Z. Jiang, Q. Liu and H. Jiang (2022). "Mitochondrial cristae architecture protects against mtDNA release and inflammation." Cell Rep 41(10): 111774.

3. Wang, G.*, Q. Li*, J. Xu, S. Zhao, R. Zhou, Z. Chen, W. Jiang, X. Gao, S. Zhou, Z. Chen, Q. Sun, C. Ma, L. Chen, B. Shi, Y. Guo, H. Wang, X. Wang, H. Li, T. Cai, Y. Wang, Z. Chen, F. Wang and Q. Liu (2022). "Somatic genetics analysis of sleep in adult mice." J Neurosci 42(28): 5617-5640.

4. Zhou, R.*, G. Wang*, Q. Li, F. Meng, C. Liu, R. Gan, D. Ju, M. Liao, J. Xu, D. Sang, X. Gao, S. Zhou, K. Wu, Q. Sun, Y. Guo, C. Wu, Z. Chen, L. Chen, B. Shi, H. Wang, X. Wang, H. Li, T. Cai, B. Li, F. Wang, H. Funato, M. Yanagisawa, E. E. Zhang and Q. Liu (2022). "A signalling pathway for transcriptional regulation of sleep amount in mice." Nature 612(7940): 519-527.

5. Deng, B.*, Q. Li*, X. Liu*, Y. Cao*, B. Li, Y. Qian, R. Xu, R. Mao, E. Zhou, W. Zhang, J. Huang and Y. Rao (2019). "Chemoconnectomics: Mapping Chemical Transmission in Drosophila." Neuron 101(5): 876-893 e874.

6. Petruccelli, E., Q. Li, Y. Rao and T. Kitamoto (2016). "The Unique Dopamine/Ecdysteroid Receptor Modulates Ethanol-Induced Sedation in Drosophila." J Neurosci 36(16): 4647-4657.

7. Song, S., Y. Yuan, J. Lu, Q. Li, Z. Zhu, Q. Fan, Y. Xue, Z. C. Lai and W. Zhang (2013). "The Drosophila ortholog of breast cancer metastasis suppressor gene, dBrms1, is critical for developmental timing through regulating ecdysone signaling." Dev Biol 380(2): 344-350.