Ting Han, Ph.D. 

Assistant Investigator, NIBS, Beijing, China

Phone: 86-10-80726688

Fax: 86-10-80726689 

E-mail: hanting@nibs.ac.cn 

Education

2006.  B.S. Biology, Tsinghua University, Beijing, China

2013.  Ph.D. Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA

Professional Experience

2017-

Assistant Investigator, National Institute of Biological Sciences, Beijing, China

2013-2017

Postdoctoral Research Fellow, UT Southwestern Medical Center, Dallas, USA

Research Description:

Cancer is a leading cause of death in China with ~4.3 million new diagnoses and ~2.8 million deaths per year. Chronic exposures to environmental mutagens further exacerbate the cancer epidemic, presenting a great challenge to our society. New and effective cancer treatment strategies are therefore urgently required. Our laboratory is interested in the discovery and development of first-in-class anti-cancer drugs that target previously undruggable proteins. Our research interests include: (1) phenotype based discovery of selective anti-cancer compounds using cancer relevant isogenic models; (2) small molecule target identification using forward genetics and chemical biology methodologies; (3) discovery of natural and artificial small molecule ligands that promote the proteolysis of oncoproteins. We will employ a combination of high throughput drug screening, forward genetics, chemical biology, and biochemical reconstitution to gain new insights in cancer biology and uncover new treatment options for cancer patients.

Publications:

1. Lv, L., Chen, P., Cao, L., Li, Y., Zeng, Z., Cui, Y., Wu, Q., Li, J., Wang, J. H., Dong, M. Q., Qi, X., & Han, T. (2020). Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Elife, 9. doi:10.7554/eLife.59994

2. Zeng, Z., & Han, T. (2020). Discovering Nature's super glue. Nat Chem Biol, 16(11), 1155-1156. doi:10.1038/s41589-020-0586-x

3. Fuller, G. G., Han, T., Freeberg, M. A., Moresco, J. J., Ghanbari Niaki, A., Roach, N. P., Yates, J. R., 3rd, Myong, S., & Kim, J. K. (2020). RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia. Elife, 9. doi:10.7554/eLife.48480

4. Zhang, J., Li, Z., Zhuo, J., Cui, Y., Han, T., & Li, C. (2019). Tandem Decarboxylative Cyclization/Alkenylation Strategy for Total Syntheses of (+)-Longirabdiol, (-)-Longirabdolactone, and (-)-Effusin. J Am Chem Soc, 141(20), 8372-8380. doi:10.1021/jacs.9b03978

5. Han, T., & Nijhawan, D. (2019). Exome Sequencing of Drug-Resistant Clones for Target Identification. Methods Mol Biol, 1888, 175-187. doi:10.1007/978-1-4939-8891-4_10

6. Han, T., Goralski, M., Gaskill, N., Capota, E., Kim, J., Ting, T. C., Xie, Y., Williams, N. S., & Nijhawan, D. (2017). Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science, 356(6336). doi:10.1126/science.aal3755

7. Jin, M., Fuller, G. G., Han, T., Yao, Y., Alessi, A. F., Freeberg, M. A., Roach, N. P., Moresco, J. J., Karnovsky, A., Baba, M., Yates, J. R., 3rd, Gitler, A. D., Inoki, K., Klionsky, D. J., & Kim, J. K. (2017). Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress. Cell Rep, 20(4), 895-908. doi:10.1016/j.celrep.2017.06.082

8. Han, T., & Kim, J. K. (2016). Mapping the Transcriptome-Wide Landscape of RBP Binding Sites Using gPAR-CLIP-seq: Experimental Procedures. Methods Mol Biol, 1361, 77-90. doi:10.1007/978-1-4939-3079-1_5

9.  Han, T., Goralski, M., Capota, E., Padrick, S. B., Kim, J., Xie, Y., & Nijhawan, D. (2016). The antitumor toxin CD437 is a direct inhibitor of DNA polymerase alpha. Nat Chem Biol, 12(7), 511-515. doi:10.1038/nchembio.2082

10. Alessi, A. F., Khivansara, V., Han, T., Freeberg, M. A., Moresco, J. J., Tu, P. G., Montoye, E., Yates, J. R., 3rd, Karp, X., & Kim, J. K. (2015). Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1. Proc Natl Acad Sci U S A, 112(52), E7213-7222. doi:10.1073/pnas.1509499112

11. Wang, G., Han, T., Nijhawan, D., Theodoropoulos, P., Naidoo, J., Yadavalli, S., Mirzaei, H., Pieper, A. A., Ready, J. M., & McKnight, S. L. (2014). P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell, 158(6), 1324-1334. doi:10.1016/j.cell.2014.07.040

12. Han, T., & Kim, J. K. (2014). Driving glioblastoma growth by alternative polyadenylation. Cell Res, 24(9), 1023-1024. doi:10.1038/cr.2014.88

13.  Freeberg, M. A., Han, T., Moresco, J. J., Kong, A., Yang, Y. C., Lu, Z. J., Yates, J. R., & Kim, J. K. (2013). Pervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae. Genome Biol, 14(2), R13. doi:10.1186/gb-2013-14-2-r13 doi:10.1371/journal.pgen.1002617

14. Billi, A. C., Alessi, A. F., Khivansara, V., Han, T., Freeberg, M., Mitani, S., & Kim, J. K. (2012). The Caenorhabditis elegans HEN1 ortholog, HENN-1, methylates and stabilizes select subclasses of germline small RNAs. PLoS Genet, 8(4), e1002617.

15. Zhao, W., Feng, D., Sun, S., Han, T., & Sui, S. (2010). The anti-viral protein of trichosanthin penetrates into human immunodeficiency virus type 1. Acta Biochim Biophys Sin (Shanghai), 42(2), 91-97. doi:10.1093/abbs/gmp111

16. Mangone, M., Manoharan, A. P., Thierry-Mieg, D., Thierry-Mieg, J., Han, T., Mackowiak, S. D., Mis, E., Zegar, C., Gutwein, M. R., Khivansara, V., Attie, O., Chen, K., Salehi-Ashtiani, K., Vidal, M., Harkins, T. T., Bouffard, P., Suzuki, Y., Sugano, S., Kohara, Y., Rajewsky, N., Piano, F., Gunsalus, K. C., & Kim, J. K. (2010). The landscape of C. elegans 3'UTRs. Science, 329(5990), 432-435. doi:10.1126/science.1191244

17. Gerstein, M. B., et al. (2010). Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science, 330(6012), 1775-1787. doi:10.1126/science.1196914

18. Han, T., Manoharan, A. P., Harkins, T. T., Bouffard, P., Fitzpatrick, C., Chu, D. S., Thierry-Mieg, D., Thierry-Mieg, J., & Kim, J. K. (2009). 26G endo-siRNAs regulate spermatogenic and zygotic gene expression in Caenorhabditis elegans. Proc Natl Acad Sci U S A, 106(44), 18674-18679. doi:10.1073/pnas.0906378106

19. Friedlander, M. R., Adamidi, C., Han, T., Lebedeva, S., Isenbarger, T. A., Hirst, M., Marra, M., Nusbaum, C., Lee, W. L., Jenkin, J. C., Sanchez Alvarado, A., Kim, J. K., & Rajewsky, N. (2009). High-resolution profiling and discovery of planarian small RNAs. Proc Natl Acad Sci U S A, 106(28), 11546-11551. doi:10.1073/pnas.0905222106

20. Li, S., Liu, C., Li, N., Hao, T., Han, T., Hill, D. E., Vidal, M., & Lin, J. D. (2008). Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism. Cell Metab, 8(2), 105-117. doi:10.1016/j.cmet.2008.06.013

Invited book chapters and review articles:

1. Han, T., and Nijhawan, D. Exome Sequencing of Drug-resistant Clones for Target Identification. Methods Mol Biol (in press)

2. Han, T., and Kim, J.K. (2016). Mapping the Transcriptome-Wide Landscape of RBP Binding Sites Using gPAR-CLIP-seq: Experimental Procedures. Methods Mol Biol 1361, 77-90.

3. Han, T., and Kim, J.K. (2014). Driving glioblastoma growth by alternative polyadenylation. Cell Res 24, 1023-1024.