Ting Han, Ph.D. Assistant Investigator, NIBS, Beijing, China

Phone: 86-10-80726688

Fax: 86-10-80726689

E-mail:hanting@nibs.ac.cn

Education

2006.  B.S. Biology, Tsinghua University, Beijing, China

2013.  Ph.D. Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA

Professional Experience

2017-

Assistant Investigator, National Institute of Biological Sciences, Beijing, China

2013-2017

Postdoctoral Research Fellow, UT Southwestern Medical Center, Dallas, USA

Research Description:

Cancer is a leading cause of death in China with ~4.3 million new diagnoses and ~2.8 million deaths per year. Chronic exposures to environmental mutagens further exacerbate the cancer epidemic, presenting a great challenge to our society. New and effective cancer treatment strategies are therefore urgently required. Our laboratory is interested in the discovery and development of first-in-class anti-cancer drugs that target previously undruggable proteins. Our research interests include: (1) phenotype based discovery of selective anti-cancer compounds using cancer relevant isogenic models; (2) small molecule target identification using forward genetics and chemical biology methodologies; (3) discovery of natural and artificial small molecule ligands that promote the proteolysis of oncoproteins. We will employ a combination of high throughput drug screening, forward genetics, chemical biology, and biochemical reconstitution to gain new insights in cancer biology and uncover new treatment options for cancer patients.

Publications:

1. Han, T., Goralski, M., Gaskill, N., Capota, E., Kim, J., Ting, T.C., Xie, Y., Williams, N.S., Nijhawan, D. (2017). Anti-cancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science (Article) 356, 397.

2. Han, T., Goralski, M., Capota, E., Padrick, S.B., Kim, J., Xie, Y., and Nijhawan, D. (2016). The antitumor toxin CD437 is a direct inhibitor of DNA polymerase alpha. Nat Chem Biol 12, 511-515.

3. Jin, M.*, Fuller, G.*, Han, T.*, Yao, Y., et al. Glycolytic Enzymes Coalesce in G-bodies Under Hypoxic Stress. Cell Reports (accepted).

4. Wang, G.*, Han, T.*, Nijhawan, D., Theodoropoulos, P., Naidoo, J., Yadavalli, S., Mirzaei, H., Pieper, A.A., Ready, J.M., and McKnight, S.L. (2014). P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell 158, 1324-1334.

5. Alessi, A.F.*, Khivansara, V.*, Han, T.*, Freeberg, M.A., Moresco, J.J., Tu, P.G., Montoye, E., Yates, J.R., 3rd, Karp, X., and Kim, J.K. (2015). Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1. PNAS 112, E7213-7222.

6. Freeberg, M.A.*, Han, T.*, Moresco, J.J., Kong, A., Yang, Y.C., Lu, Z.J., Yates, J.R., 3rd, and Kim, J.K. (2013). Pervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae. Genome biology 14, R13.

7. Billi, A.C., Alessi, A.F., Khivansara, V., Han, T., Freeberg, M., Mitani, S., and Kim, J.K. (2012). The Caenorhabditis elegans HEN1 ortholog, HENN-1, methylates and stabilizes select subclasses of germline small RNAs. PLoS genetics 8, e1002617.

8. Gerstein, M.B., Lu, Z.J., Van Nostrand, E.L., Cheng, C., Arshinoff, B.I., Liu, T., Yip, K.Y., Robilotto, R., Rechtsteiner, A., Ikegami, K., et al. (2010). Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science 330, 1775-1787.

9. Mangone, M.*, Manoharan, A.P.*, Thierry-Mieg, D.*, Thierry-Mieg, J.*, Han, T.*, et al. (2010). The landscape of C. elegans 3'UTRs. Science 329, 432-435.

10. Han, T., Manoharan, A.P., Harkins, T.T., Bouffard, P., Fitzpatrick, C., Chu, D.S., Thierry-Mieg, D., Thierry-Mieg, J., and Kim, J.K. (2009). 26G endo-siRNAs regulate spermatogenic and zygotic gene expression in Caenorhabditis elegans. PNAS 106, 18674-18679.

11. Friedlander, M.R., Adamidi, C., Han, T., et al. (2009). High-resolution profiling and discovery of planarian small RNAs. PNAS 106, 11546-11551.

12. Li, S., Liu, C., Li, N., Hao, T., Han, T., Hill, D.E., Vidal, M., and Lin, J.D. (2008). Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism. Cell metabolism 8, 105-117.

Invited book chapters and review articles:

1. Han, T., and Nijhawan, D. Exome Sequencing of Drug-resistant Clones for Target Identification. Methods Mol Biol (in press)

2. Han, T., and Kim, J.K. (2016). Mapping the Transcriptome-Wide Landscape of RBP Binding Sites Using gPAR-CLIP-seq: Experimental Procedures. Methods Mol Biol 1361, 77-90.

3. Han, T., and Kim, J.K. (2014). Driving glioblastoma growth by alternative polyadenylation. Cell Res 24, 1023-1024.