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实验室

张昱 博士

 

发表文章

Publications

1. Lu G*, Duan J*, Shu S, Wang X, Gao L, Guo J, Zhang Y #. Ligase I and ligase III mediate the DNA double strand break ligation in Alternative End-joining. Proc Natl Acad Sci U S A. 2016. 113(5):1256-60. (*Contributed equally to this work) (#corresponding author) link

2. Dong J, Rohit A, Zhang T, Zhang Y, Hu J, Sabrina A, Robin M, Ho Y, Du Z, Davide F, Meng F, Monica G, Michel C, John P, Frederick W, Alt FW. Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching. Nature. 2015. 525:134–139link

3. Duan J*, Lu G*, Xie Z, Lou M, Luo J, Guo L, Zhang Y #. Genome-wide identification of CRISPR/Cas9 off-targets in human genome. Cell Res. 2014. Aug;24(8):1009-12. (*Contributed equally to this work) (#corresponding author)link

4. Subrahmanyam R, Du H, Ivanova I, Chakraborty T, Ji Y, Zhang Y, Alt FW, Schatz DG, Sen R. Localized epigenetic changes induced by D(H) recombination restricts recombinase to DJ(H) junctions. Nat Immunol. 2012. 13:1205-12 link

5. Zhang Y*, McCord RP*, Ho YJ, Lajoie BR, Dominic HG, Simon AC, Becker MS, Alt FW# and Dekker J#. Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell. 2012. 148:908-21 (*Contributed equally to this work) (#corresponding author)

6. Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Mila Jankovic, Albertorio Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, and Schwer B. Robust Chromosomal DSB Repair Via Alternative End-Joining in the Absence of XRCC1. Proc Natl Acad Sci U S A. 2012.  109:2455-60 link

7. Chiarle R*, Zhang Y*#, Frock RL*, Lewis SM*, Molinie B, Ho YJ, Myers DR, Choi VW, Compagno M, Malkin DJ, Neuberg D, Monti S, Giallourakis CC#, Gostissa M#, Alt FW#. Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells. Cell. 2011. 147: 107-19 (*Contributed equally to this work) (#corresponding author) link

8. Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature. 2011. 469: 250-4link

9. Yamaguchi T, Cubizolles F, Zhang Y, Reichert N, Kohler H, Seiser C, Matthias P. Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression. Genes Dev. 2010. 24: 455-69 link

10. Grausenburger R, Bilic I, Boucheron N, Zupkovitz G, El-Housseiny L, Tschismarov R, Zhang Y, Rembold M, Gaisberger M, Hartl A, Epstein MM, Matthias P, Seiser C, Ellmeier W. Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production. J Immunol. 2010. 185: 3489-97 link

11. Brunmeir R, Lagger S, Simboeck E, Sawicka A, Egger G, Hagelkruys A, Zhang Y, Matthias P, Miller WJ, Seiser C. Epigenetic regulation of a murine retrotransposon by a dual histone modification mark. PLoS Genet. 2010. 6: e1000927link

12. Chakraborty T, Perlot T, Subrahmanyam R, Jani A, Goff PH, Zhang Y, Ivanova I, Alt FW, Sen R.  A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation. J Exp Med. 2009. 206: 1019-27 link

13. Zhang Y, Kwon S, Yamaguchi T, Cubizolles F, Rousseaux S, Kneissel M, Cao C, Li N, Cheng HL, Chua K, Lombard D, Mizeracki A, Matthias G, Alt FW, Khochbin S, Matthias P. Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol. 2008. 28: 1688-701 link

14. Li G, Alt FW, Cheng HL, Brush JW, Goff PH, Murphy MM, Franco S, Zhang Y, Zha S. Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell. 2008. 31: 631-40 link

15. Kwon S, Zhang Y, Matthias P. The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response. Genes Dev. 2007. 21: 3381-94 link

16. Boyault C*, Zhang Y*, Fritah S*, Caron C, Gilquin B, Kwon SH, Garrido C, YaoTP, Vourc'h C, Matthias P, Khochbin S. HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 2007. 21: 2172-81(*Contributed equally to this work) link

17. Zhang Y, Gilquin B, Khochbin S, Matthias P. Two catalytic domains are required for protein deacetylation. J Biol Chem. 2006. 281: 2401-4 link

18. Yan CT, Kaushal D, Murphy M, Zhang Y, Datta A, Chen C, Monroe B, Mostoslavsky G, Coakley K, Gao Y, Mills KD, Fazeli AP, Tepsuporn S, Hall G, Mulligan R, Fox E, Bronson R, De Girolami U, Lee C, Alt FW. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci U S A. 2006. 103: 7378-83 link

19. Boyault C, Gilquin B, Zhang Y, Rybin V, Garman E, Meyer-Klaucke W, Matthias P, Muller CW, Khochbin S. HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J. 2006. 25: 3357-66 link

20. Li N, Zhang Y, Naylor MJ, Schatzmann F, Maurer F, Wintermantel T, Schuetz G, Mueller U, Streuli CH, Hynes NE. Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. EMBO J. 2005. 20: 1942-53 link

21. Zhang Y, Li N, Caron C, Matthias G, Hess D, Khochbin S, Matthias P. HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J. 2003. 22: 1168-79 link

22. He Z, Bai J, Zhang Y. Effect of DNA methylation on protein-DNA interaction of HL-60 cells. Sci China C Life Sci. 1999. 42: 501-5 link

INVITED REVIEW ARTICLE

1. Zhang Y, Gostissa M, Hildebrand DG, Becker MS, Boboila C, Chiarle R, Lewis S, Alt FW.The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv Immunol. 2010.  106: 93-133

2. Alt FW#, Zhang Y, Meng F, Guo C, Schwer B. Mechanisms of programmed DNA lesions and genomic instability in the immune system. Cell. 2013. 152:417-29 (#corresponding author)