当前位置:首页 / 科学研究 / 实验室 / 正文

实验室

11:00-12:00, Friday, September 14, 2018

Speaker: Yuru Liu, Ph. D.

Department of Pharmacology

College of Medicine; University of Illinois at Chicago

Topic: The Role of Alveolar Type II Cells in Lung Repair

Host:   Nan Tang, Ph.D.

Abstract

The alveolar epithelium is composed of the flat type I cells comprising 95% of the gas-exchange surface area and cuboidal type II cells comprising the rest. Type II cells are described as facultative progenitor cells based on their ability to proliferate and trans-differentiate into type I cells.  Using a translationally relevant mouse lung injury model by i.t. Pseudomonas aeruginosa, we have  identified Sca-1 as markers for reparative type II cells. The progenitor phenotype of the Sp-C+Sca-1+ type II cells that mediates alveolar epithelial repair might involve Wnt signaling.  Furthermore, we  observed that the forkhead transcription factor FoxM1 was preferentially expressed in the Sca-1+ sub-population of progenitor type II cells.  In mice lacking FoxM1 specifically in type II cells, type II cells showed decreased proliferation and impaired trans-differentiation into type I cells.  Lungs of these mice also displayed defective alveolar barrier repair post-injury.  Recently, we have initiated new studies on Notch and Sphingosin-1-phosphate signaling as essential regulators of type II cell mediated repair. To summarize, using combinatorial approaches including mouse genetic lineage tracing analysis, tissue specific inducible gene targeting techniques, and 2D and 3D in vitro culture, we hope to fill an important gap in knowledge about the molecular mechanisms underlying alveolar repair. We believe that these studies will lead to the discovery of therapeutic targets to accelerate lung repair and prevent chronic pathological conditions resulting from improper recovery.