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实验室

10:30-11:30, Monday, April 8, 2018


Speaker: Robert Wolfe Greene, Ph.D. M.D.

Topic: Adenosine mediates the homeostatic sleep response via a glia-neuronal circuit

Host: Qinghua Liu, Ph.D.

Abstract

The function of sleep remains as one of the great enigmas of modern biology. Its importance is emphasized by the homeostatic sleep response (HSR) to the loss of normal sleep. The greater the time spent awake (and thus greater the loss of sleep) the greater the need for sleep as indicated by direct correlation to slow wave activity (SWA) intensity. SWA after sleep loss rebounds up to several fold over baseline during the ensuing sleep time. As sleep need resolves, so does the SWA intensity. The remarkable expression of this biomarker is controlled  by adenosine as part of a neuronal-glial circuit linking glial metabolic state to neuronal excitability. We are exploring the possibility that this HSR-SWA signals sleep function through a reprogramming of cellular genomic activity.