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实验室

11:00-12:00, Tuesday, August 13, 2019


Speaker:  Shan-Lu Liu, MD, PhD

Professor, Director, Viruses and Emerging Pathogens Program,

Infectious Diseases Institute,

Investigator, Center for Retrovirus Research,

The Ohio State University

Topic:  The Ins and Outs of Virus-Host Interaction: Studies of HIV/AIDS, Influenza, Ebola and Zika

Host:    Feng Shao, Ph.D.

Abstract

The interferon (IFN) system is the first line of host defense against pathogen invasion, including viral infections. Shortly after IFN induction or viral infection, cells express hundreds of IFN-stimulated genes (ISGs) that block viral replication. Notably, viral infections are also modulated by some atypical host factors. In this talk, Dr. Liu will discuss how some classical ISGs, such as IFN-induced transmembrane (IFITM) proteins, as well as non-classical host factors, including TIM and SERINC proteins, block different stages of viral replication. Dr. Liu will use HIV, influenza A virus (IAV), Ebolavirus (EBOV), and Zika virus as model to illustrate how host restriction occurs viral as well as how viral proteins antagonize the host restriction, which drives the virus-host co-evolution and viral pathogenesis.