当前位置:首页 / 科学研究 / 实验室 / 正文

实验室

10:00-11:00, Thursday, September 12, 2019


Speaker:Luis de Lecea, Ph.D.

Professor of Psychiatry and Behavioral Sciences,

Stanford University School of Medicine

Topic: To sleep or not to sleep: How the brain decides to wake us up

Host:  Qinghua Liu, Ph.D.

Abstract

The arousal construct underlies a spectrum of behaviors that include sleep, exploration, feeding, sexual activity and adaptive stress. Pathological arousal conditions include stress, anxiety disorders, and addiction. In the past few years we have used optogenetics to interrogate neuronal circuits underlying transitions between arousal states. In particular, I will talk about how the hypocretin system, makes the decisions about when to mark the transition between sleep and wakefulness. The dynamics between arousal state transitions are also modulated by norepinephrine neurons in the locus coeruleus, histaminergic neurons in the hypothalamus, dopaminergic neurons in the mesencephalon and cholinergic neurons in the basal forebrain.  I will talk about an attempt to model sleep/wake dynamics using probabilistic estimates of neurotransmitter function based on optogenetic stimulations. Examples of dysfunctional arousal circuits in the aging brain will also be presented and discussed.