Original Research Articles

1. Chang, J., C. Guo, J. Li, Z. Liang, Y. Wang, A. Yu, R. Liu, Y. Guo, J. Chen and S. Huang, EN1 Regulates Cell Growth and Proliferation in Human Glioma Cells via Hedgehog Signaling, Int J Mol Sci, 23:1422-0067, 10.3390/ijms23031123(2022).

2. Chen, J., C. Li, Z. Lu and C. Zhan, Optimal Timing of a Commonly-Used Rabies Virus for Neural Recording and Manipulation, Neurosci Bull, 1995-8218, 10.1007/s12264-022-00819-8(2022).

3. Chen, S., X. Teng and S. Zheng, Molecular basis for the selective G protein signaling of somatostatin receptors, Nature Chemical Biology, 1552-4469, 10.1038/s41589-022-01130-3(2022).

4. Cui, B., B. Yan, K. Wang, L. Li, S. Chen and Z. Zhang, Discovery of a New Class of Uracil Derivatives as Potential Mixed Lineage Kinase Domain-like Protein (MLKL) Inhibitors, Journal of Medicinal Chemistry, 0022-2623, 10.1021/acs.jmedchem.2c00548(2022).

5. Dai, R., T. Yu, D. Weng, H. Li, Y. Cui, Z. Wu, Q. Guo, H. Zou, W. Wu, X. Gao, Z. Qi, Y. Ren, S. Wang, Y. Li and M. Luo, A neuropsin-based optogenetic tool for precise control of Gq signaling, Science China Life Sciences, 1869-1889, 10.1007/s11427-022-2122-0(2022).

6. De Carvalho, M., G.-S. Jia, A. Nidamangala Srinivasa, R. B. Billmyre, Y.-H. Xu, J. J. Lange, I. M. Sabbarini, L.-L. Du and S. E. Zanders, The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years, eLife, 11( e81149):2050-084X, 10.7554/eLife.81149(2022).

7. Guo, J., G. Cai, Y. Q. Li, Y. X. Zhang, Y. N. Su, D. Y. Yuan, Z. C. Zhang, Z. Z. Liu, X. W. Cai, J. Guo, L. Li, S. Chen and X. J. He, Comprehensive characterization of three classes of Arabidopsis SWI/SNF chromatin remodelling complexes, Nat Plants, 2055-0278, 10.1038/s41477-022-01282-z(2022).

8. Guo, J., Z. Guo, Y. Huang, S. Ma, B. Yan, C. Pan, Z. Jiang, F. Wang, Z. Zhang, Y. Da, X. Wang and Z. Ying, Blockage of MLKL prevents myelin damage in experimental diabetic neuropathy, Proc Natl Acad Sci U S A, 119(e2121552119):0027-8424, 10.1073/pnas.2121552119(2022).

9. Guo, X., Y. Zhang, H. Huang and R. Xi, A hierarchical transcription factor cascade regulates enteroendocrine cell diversity and plasticity in Drosophila, Nat Commun, 13(6525):2041-1723,10.1038/s41467-022-34270-0(2022).

10. Han, Y., L. Peng and T. Wang, Tadr is an axonal histidine transporter required for visual neurotransmission in Drosophila, Elife, 11：2050-084x， 10.7554/eLife.75821(2022).

11. He, B., H. Yu, S. Liu, H. Wan, S. Fu, S. Liu, J. Yang, Z. Zhang, H. Huang, Q. Li, F. Wang, Z. Jiang, Q. Liu and H. Jiang, Mitochondrial cristae architecture protects against mtDNA release and inflammation, Cell Reports，41(111774):2211-1247, https://doi.org/10.1016/j.celrep.2022.111774(2022).

12. Jiang, W., L. Jin, D. Ju, Z. Lu, C. Wang, X. Guo, H. Zhao, S. Shen, Z. Cheng, J. Shen, G. Zong, J. Chen, K. Li, L. Yang, Z. Zhang, Y. Feng, J. Z. Shen, E. E. Zhang and R. Wan, The pancreatic clock is a key determinant of pancreatic fibrosis progression and exocrine dysfunction, Science Translational Medicine,  14:eabn3586, 10.1126/scitranslmed.abn3586(2022).

13. Jiang, W. and S. Zheng, Structural insights into galanin receptor signaling, Proceedings of the National Academy of Sciences, 119:e2121465119, 10.1073/pnas.2121465119(2022).

14. Jin, Z., M. Che and R. Xi, Chapter 11 - Identification of progenitor cells and their progenies in adult Drosophila midgut, Methods in Cell Biology, 170(169-187):0091-679X, 10.1016/bs.mcb.2022.02.013(2022).

15. Li, L., L. Lu, Y. Ren, G. Tang, Y. Zhao, X. Cai, Z. Shi, H. Ding, C. Liu, D. Cheng, Y. Xie, H. Wang, X. Fu, L. Yin, M. Luo and X. Sheng, Colocalized, bidirectional optogenetic modulations in freely behaving mice with a wireless dual-color optoelectronic probe, Nat Commun, 13(839):2041-1723, 10.1038/s41467-022-28539-7(2022).

16. Li, Y., R. Meng, S. Li, B. Gu, X. Xu, H. Zhang, X. Tan, T. Shao, J. Wang, D. Xu and F. Wang, The ZFP541-KCTD19 complex is essential for pachytene progression by activating meiotic genes during mouse spermatogenesis, J Genet Genomics, 1673-8527 (Print), 10.1016/j.jgg.2022.03.005(2022).

17. Li, Y., Z. Wang, L. Li, X. Tian, F. Shao and C. Li , Chemoselective and Diastereoselective Synthesis of C-Aryl Nucleoside Analogues by Nickel-Catalyzed Cross-Coupling of Furanosyl Acetates with Aryl Iodides, Angew Chem Int Ed Engl, 61(e202110391):1521-3773(Electronic), 10.1002/anie.202110391(2022).

18. Lin, R., Y. Zhou, T. Yan, R. Wang, H. Li, Z. Wu, X. Zhang, X. Zhou, F. Zhao, L. Zhang, Y. Li and M. Luo, Directed evolution of adeno-associated virus for efficient gene delivery to microglia, Nature Methods, 19(976-985):1548-7105,10.1038/s41592-022-01547-7(2022).

19. Liu, N., H. Tian, Z. Yu, H. Zhao, W. Li, D. Sang, K. Lin, Y. Cui, M. Liao, Z. Xu, C. Chen, Y. Guo, Y. Wang, H.-w. Huang, J. Wang, H. Zhang, W. Wu, H. Huang, S. Lv, Z. Guo, W. Wang, S. Zheng, F. Wang, Y. Zhang, T. Cai and E. E. Zhang, A highland-adaptation mutation of the Epas1 protein increases its stability and disrupts the circadian clock in the plateau pika, Cell Reports, 39(110816):2211-1247, https://doi.org/10.1016/j.celrep.2022.110816(2022).

20. Liu, X., M. Lou, S. Bai, G. Sun and X. Qi, Asymmetric Total Syntheses of Strychnos Alkaloids via Selective Fischer Indolization, J Org Chem, 0022-3263, 10.1021/acs.joc.2c00015(2022).

21. Liu, X., X. Tian, X. Hao, H. Zhang, K. Wang, Z. Wei, X. Wei, Y. Li and J. Sui, A cross-reactive pH-dependent EGFR antibody with improved tumor selectivity and penetration obtained by structure-guided engineering, Mol Ther Oncolytics, 27(256-269):2372-7705 (Print), 10.1016/j.omto.2022.11.001(2022).

22. Liu, X., X. Tian, X. Hao, H. Zhang, K. Wang, Z. Wei, X. Wei, Y. Li and J. Sui, Calmodulin Binding Activates Chromobacterium CopC Effector to ADP-Riboxanate Host Apoptotic Caspases, mBio, 0(e00690-00622), 2150-7511, 10.1128/mbio.00690-22(2022).

23. Liu, Z. and P. Cao, Love or not? A new subpopulation of neurons controls the switch of female sexual behavior , Neuron, 110(2893-2895):0896-6273, https://doi.org/10.1016/j.neuron.2022.08.008(2022).

24. Ma, Y., Y. Cao, X. Song, Y. Zhang, J. Li, Y. Wang, X. Wu and X. Qi, BAFinder: A Software for Unknown Bile Acid Identification Using Accurate Mass LC-MS/MS in Positive and Negative Modes, Analytical Chemistry, 0003-2700, 10.1021/acs.analchem.1c05648(2022).

25. Pan, Z. Q., K. Ye and L. L. Du, The hallmark domain of the oldest autophagy receptor family is a cargo-binding module, Autophagy, 1554-8627, 10.1080/15548627.2022.2123636(2022).

26. Peng, B., Z. Jing, Z. Zhou, Y. Sun, G. Guo, Z. Tan, Y. Diao, Q. Yao, Y. Ping, X. Li, T. Ren, B. Li and W. Li, Nonproductive Hepatitis B Virus Covalently Closed Circular DNA Generates HBx-Related Transcripts from the HBx/Enhancer I Region and Acquires Reactivation by Superinfection in Single Cells, J Virol, e0171722:0022-538x, 10.1128/jvi.01717-22(2022).

27. Qi, P.-L., H.-R. Zhou, Q.-Q. Zhao, C. Feng, Y.-Q. Ning, Y.-N. Su, X.-W. Cai, D.-Y. Yuan, Z.-C. Zhang, X.-M. Su, S.-S. Chen, L. Li, S. Chen and X.-J. He, Characterization of an autonomous pathway complex that promotes flowering in Arabidopsis, Nucleic Acids Research, gkac551:0305-1048, 10.1093/nar/gkac551(2022).

28. Qin, Y. and G. Xu Guotai Xu, Enhancing CAR T-cell therapies against solid tumors: Mechanisms and reversion of resistance, Front Immunol , 13(1053120):1664-3224, 10.3389/fimmu.2022.1053120(2022).

29. Ren, Y., Y. Liu, S. Zheng and M. Luo, KCTD8 and KCTD12 Facilitate Axonal Expression of GABA(B) Receptors in Habenula Cholinergic Neurons, J Neurosci, 42(1648-1665):0270-6474 (Print), 10.1523/jneurosci.1676-21.2021(2022).

30. Shang, J. Y., X. W. Cai, Y. N. Su, Z. C. Zhang, X. Wang, N. Zhao and X. J. He Arabidopsis Trithorax histone methyltransferases are redundant in regulating development and DNA methylation, J Integr Plant Biol, 1672-9072, 10.1111/jipb.13406(2022).

31. Shang, J. Y. and X. J. He Xin-Jian He, Chromatin-remodeling complexes: Conserved and plant-specific subunits in Arabidopsis, J Integr Plant Biol, 64(499-515):1672-9072, 10.1111/jipb.13208(2022).

32. Shao, F. and K. A. Fitzgerald, Molecular mechanisms and functions of pyroptosis, J Mol Biol, 434(167461):0022-2836, 10.1016/j.jmb.2022.167461(2022).

33. Tao, Z., Y. Cui, X. Xu and T. Han, FGFR redundancy limits the efficacy of FGFR4-selective inhibitors in hepatocellular carcinoma, Proceedings of the National Academy of Sciences, 119(e2208844119), 10.1073/pnas.2208844119(2022).

34. Teng, X., S. Chen, Y. Nie, P. Xiao, X. Yu, Z. Shao and S. Zheng, Ligand recognition and biased agonism of the D1 dopamine receptor, Nature Communications, 13:2041-1723, 10.1038/s41467-022-30929-w(2022).

35. Teng, X., S. Chen, Q. Wang, Z. Chen, X. Wang, N. Huang and S. Zheng, Structural insights into G protein activation by D1 dopamine receptor, Science Advances, 8(eabo4158):2375-2548, 10.1126/sciadv.abo4158(2022).

36. Tian, X., X. Liu, J. Ding, F. Wang, K. Wang, J. Liu, Z. Wei, X. Hao, Y. Li, X. Wei, H. Zhang and J. Sui, An anti-CD98 antibody displaying pH-dependent Fc-mediated tumour-specific activity against multiple cancers in CD98-humanized mice, Nat Biomed Eng, 2157-846x, 10.1038/s41551-022-00956-5(2022).

37. Wang, G., Q. Li, J. Xu, S. Zhao, R. Zhou, Z. Chen, W. Jiang, X. Gao, S. Zhou, Z. Chen, Q. Sun, C. Ma, L. Chen, B. Shi, Y. Guo, H. Wang, X. Wang, H. Li, T. Cai, Y. Wang, Z. Chen, F. Wang and Q. Liu, Somatic genetics analysis of sleep in adult mice, J Neurosci, 1529-2401 (Electronic), 10.1523/JNEUROSCI.0089-22.2022(2022).

38. Xie, J., Y. Han, Y. Liang, L. Peng and T. Wang, Drosophila HisT is a specific histamine transporter that contributes to histamine recycling in glia, Science Advances, 8(eabq1780), 10.1126/sciadv.abq1780(2022).

39. Xie, Y., D. Chen, K. Jiang, L. Song, N. Qian, Y. Du, Y. Yang, F. Wang and T. Chen, Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis, Cell Stem Cell, 29(70-85.e76):1875-9777, 10.1016/j.stem.2021.09.009(2022).

40. Xie, Z., H. Gu, M. Huang, X. Cheng, C. Shang, T. Tao, D. Li, Y. Xie, J. Zhao, W. Lu, Z. Zhang, C. Zhan, Z. Tang, F. Zhang and P. Cao, Mechanically evoked defensive attack is controlled by GABAergic neurons in the anterior hypothalamic nucleus, Nat Neurosci, 25(72-85):1097-6256, 10.1038/s41593-021-00985-4(2022).

41. Xie, Z., D. Li, X. Cheng, Q. Pei, H. Gu, T. Tao, M. Huang, C. Shang, D. Geng, M. Zhao, A. Liu, C. Zhang, F. Zhang, Y. Ma and P. Cao, A brain-to-spinal sensorimotor loop for repetitive self-grooming, Neuron, 110(874-890.e877):0896-6273, 10.1016/j.neuron.2021.11.028(2022).

42. Xie, Z., X. Zhang, M. Zhao, L. Huo, M. Huang, D. Li, S. Zhang, X. Cheng, H. Gu, C. Zhang, C. Zhan, F. Wang, C. Shang and P. Cao, The gut-to-brain axis for toxin-induced defensive responses, Cell, 185(4298-4316.e4221):0092-8674, https://doi.org/10.1016/j.cell.2022.10.001(2022).

43. Xu, D. D. and L. L. Du, Fission Yeast Autophagy Machinery, Cells, 11:2073-4409 (Electronic), 10.3390/cells11071086(2022).

44. Xu, J., C. Shen, Y. Xie, B. Qiu, X. Ren, Y. Zhou, G. Li, G. Zheng and N. Huang, Design, synthesis, and bioactivity evaluation of macrocyclic benzo[b]pyrido[4,3-e][1,4]oxazine derivatives as novel Pim-1 kinase inhibitors, Bioorganic & Medicinal Chemistry Letters, 72(128874):0960-894X, https://doi.org/10.1016/j.bmcl.2022.128874(2022).

45. Xu, J., R. Zhou, G. Wang, Y. Guo, X. Gao, S. Zhou, C. Ma, L. Chen, B. Shi, H. Wang, F. Wang and Q. Liu, Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinase, Sleep, zsac198:0161-8105, 10.1093/sleep/zsac198(2022).

46. Xu, M., C. Shen, J. Yang, Q. Wang and N. Huang, Systematic Investigation of Docking Failures in Large-Scale Structure-Based Virtual Screening, ACS Omega,  7(39417-39428):2470-1343, 10.1021/acsomega.2c05826(2022).

47. Xu, Y., S. Cheng, H. Zeng, P. Zhou, Y. Ma, L. Li, X. Liu, F. Shao and J. Ding, ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy, Nat Struct Mol Biol, 29(67-77):1545-9985, 10.1038/s41594-021-00710-6(2022).

48. Yuan, H., Y. Zhu, Y. Cheng, J. Hou, F. Jin, M. Li, W. Jia, Z. Cheng, H. Xing, M. Liu and T. Han, BTK kinase activity is dispensable for the survival of diffuse large B-cell lymphoma, Journal of Biological Chemistry, 102555:0021-9258, https://doi.org/10.1016/j.jbc.2022.102555(2022).

49. Zhai, C., N. Zhang, X. X. Li, X. Chen, F. Sun and M. Q. Dong, Fusion and expansion of vitellogenin vesicles during Caenorhabditis elegans intestinal senescence, Aging Cell, e13719:1474-9718, 10.1111/acel.13719(2022).

50. Zhang, J., Y. Y. Wang, Z. Q. Pan, Y. Li, J. Sui, L. L. Du and K. Ye, Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1, Nat Commun, 13(3650):2041-1723, 10.1038/s41467-022-31439-5(2022).

51. Zhang, W., W. Fan, J. Guo and X. Wang, Osmotic stress activates RIPK3/MLKL-mediated necroptosis by increasing cytosolic pH through a plasma membrane Na+/H+ exchanger, Science Signaling, 15(eabn5881):1937-9145, 10.1126/scisignal.abn5881(2022).

52. Zhang, X. R., L. Zhao, F. Suo, Y. Gao, Q. Wu, X. Qi and L. L. Du, An improved auxin-inducible degron system for fission yeast, G3 (Bethesda), 12:2160-1836, 10.1093/g3journal/jkab393(2022).

53. Zhang, Y.-P., W.-H. Zhang, P. Zhang, Q. Li, Y. Sun, J.-W. Wang, S. O. Zhang, T. Cai, C. Zhan and M.-Q. Dong, Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost, Nature Communications ,  13(6339):2041-1723, 10.1038/s41467-022-33850-4(2022).

54. Zhao, N., X. M. Su, Z. W. Liu, J. X. Zhou, Y. N. Su, X. W. Cai, L. Chen, Z. Wu and X. J. He , The RNA recognition motif-containing protein UBA2c prevents early flowering by promoting transcription of the flowering repressor FLM in Arabidopsis, New Phytol, 233(751-765):0028-646x, 10.1111/nph.17836(2022).

55. Zhao, Y., L. Li, X. Wang, S. He, W. Shi and S. Chen, Temporal Proteomic and Phosphoproteomic Analysis of EV-A71-Infected Human Cells , Journal of Proteome Research, 1535-3893, 10.1021/acs.jproteome.2c00237(2022).

56. Zheng, J., Y. Cao, J. Yang and H. Jiang, UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy, EMBO Rep, e54859:1469-3178 (Electronic), 10.15252/embr.202254859(2022).

57. Zhou, J. X., X. M. Su, S. Y. Zheng, C. J. Wu, Y. N. Su, Z. Jiang, L. Li, S. Chen and X. J. He, The Arabidopsis NuA4 histone acetyltransferase complex is required for chlorophyll biosynthesis and photosynthesis, J Integr Plant Biol, 1672-9072, 10.1111/jipb.13227(2022).

58. Zhou, R., G. Wang, Q. Li, F. Meng, C. Liu, R. Gan, D. Ju, M. Liao, J. Xu, D. Sang, X. Gao, S. Zhou, K. Wu, Q. Sun, Y. Guo, C. Wu, Z. Chen, L. Chen, B. Shi, H. Wang, X. Wang, H. Li, T. Cai, B. Li, F. Wang, H. Funato, M. Yanagisawa, E. E. Zhang and Q. Liu, A signalling pathway for transcriptional regulation of sleep amount in mice, Nature, 0028-0836, 10.1038/s41586-022-05510-6(2022).

59. Zhu, H., J. Yang and N. Huang, Assessment of the Generalization Abilities of Machine-Learning Scoring Functions for Structure-Based Virtual Screening, Journal of Chemical Information and Modeling, 1549-9596, 10.1021/acs.jcim.2c01149(2022).

60. Zhu, H., Y. Zhang, W. Li and N. Huang, A Comprehensive Survey of Prospective Structure-Based Virtual Screening for Early Drug Discovery in the Past Fifteen Years, Int J Mol Sci, 23:1422-0067, 10.3390/ijms232415961(2022).

61. Zhuo, J., C. Zhu, J. Wu, Z. Li and C. Li, Reductive Radical Annulation Strategy toward Bicyclo[3.2.1]octanes: Synthesis of ent-Kaurane and Beyerane Diterpenoids, J Am Chem Soc, 144(99-105):0002-7863, 10.1021/jacs.1c11623(2022).

62. Wang JH, Tang YL, Gong Z, Jain R, Xiao F, Zhou Y, Tan D, Li Q, Huang N, Liu SQ, Ye K, Tang C*, Dong MQ*, Lei X*, Characterization of protein unfolding by fast cross-linking mass spectrometry using di-ortho-phthalaldehyde cross-linkers, Nature Communications, 13(1468):2041-1723, 10.1038/s41467-022-28879-4(2022).

63. Qi, X. and W. Li, Unlocking the secrets to human NTCP structure, The Innovation, 3(5):2666-6758, https://doi.org/10.1016/j.xinn.2022.100294(2022).

64. Liu, Y., S. Bai, Y. Du, X. Qi and H. Gao , Expeditious and Efficient ortho-Selective Trifluoromethane-sulfonylation of Arylhydroxylamines, Angew Chem Int Ed Engl, 61(e202115611):1433-7851, 10.1002/anie.202115611(2022).

65. Gen Li, Mingliang Lou, Xiangbing Qi, A brief overview of classical natural product drug synthesis and bioactivity, Org Chem Front,  9(517-571):2052-4129, 10.1039/D1QO01341F(2022).