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科学研究

2012

Original Research Articles

  1. Zou, Wei*, Wang, Xiaochen, Vale, Ronald D & Ou, Guangshuo. Autophagy genes promote apoptotic cell corpse clearance. Autophagy 8, 1267-1268, doi:10.4161/auto.20786 (2012).


  2. Zhao, Yanmei, Sun, Wei, Zhang, Pan, Chi, Hao, Zhang, Mei-Jun, Song, Chun-Qing, Ma, Xuan, Shang, Yunlong, Wang, Bin, Hu, Youqiao, Hao, Zhiqi, Huhmer, Andreas F, Meng, Fanxia, L'hernault, Steven W, He, Si-Min, Dong, Meng-Qiu* & Miao, Long*. Nematode sperm maturation triggered by protease involves sperm-secreted serine protease inhibitor (Serpin). Proc Natl Acad Sci U S A 109, 1542-1547, doi:10.1073/pnas.1109912109 (2012).


  3. Zhao, Yue & Shao, Feng*. NLRC5: a NOD-like receptor protein with many faces in immune regulation. Cell Res 22, 1099-1101, doi:10.1038/cr.2012.83 (2012).


  4. Zhang, Zhibin, Wu, Yaling, Gao, Minghui, Zhang, Jie, Kong, Qing, Liu, Yanan, Ba, Hongping, Zhou, Jianmin & Zhang, Yuelin*. Disruption of PAMP-induced MAP kinase cascade by a Pseudomonas syringae effector activates plant immunity mediated by the NB-LRR protein SUMM2. Cell Host Microbe 11, 253-263, doi:10.1016/j.chom.2012.01.015 (2012).


  5. Zhang, Cui-Jun, Ning, Yong-Qiang, Zhang, Su-Wei, Chen, Qing, Shao, Chang-Rong, Guo, Yan-Wu, Zhou, Jin-Xing, Li, Lin, Chen, She & He, Xin-Jian*. IDN2 and its paralogs form a complex required for RNA-directed DNA methylation. PLoS Genet 8, e1002693, doi:10.1371/journal.pgen.1002693 (2012).


  6. Yuan, Wen#, Wu, Tong#, Fu, Hang#, Dai, Chao, Wu, Hui, Liu, Nan, Li, Xiang, Xu, Mo, Zhang, Zhuqiang, Niu, Tianhui, Han, Zhifu, Chai, Jijie, Zhou, Xianghong Jasmine, Gao, Shaorong* & Zhu, Bing*. Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. Science 337, 971-975, doi:10.1126/science.1225237 (2012).


  7. Yao, Q., Cui, J., Wang, J., Li, T., Wan, X., Luo, T., Gong, Y. N., Xu, Y., Huang, N. & Shao, F. Structural mechanism of ubiquitin and NEDD8 deamidation catalyzed by bacterial effectors that induce macrophage-specific apoptosis. Proc Natl Acad Sci U S A 109, 20395-20400, doi:10.1073/pnas.1210831109 (2012).


  8. Yang, Bing, Wu, Yan-Jie, Zhu, Ming, Fan, Sheng-Bo, Lin, Jinzhong, Zhang, Kun, Li, Shuang, Chi, Hao, Li, Yu-Xin, Chen, Hai-Feng, Luo, Shu-Kun, Ding, Yue-He, Wang, Le-Heng, Hao, Zhiqi, Xiu, Li-Yun, Chen, She, Ye, Keqiong, He, Si-Min* & Dong, Meng-Qiu*. Identification of cross-linked peptides from complex samples. Nat Methods 9, 904-906, doi:10.1038/nmeth.2099 (2012).


  9. Yan, Huan, Zhong, Guocai, Xu, Guangwei, He, Wenhui, Jing, Zhiyi, Gao, Zhenchao, Huang, Yi, Qi, Yonghe, Peng, Bo, Wang, Haimin, Fu, Liran, Song, Mei, Chen, Pan, Gao, Wenqing, Ren, Bijie, Sun, Yinyan, Cai, Tao, Feng, Xiaofeng, Sui, Jianhua & Li, Wenhui*. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Elife 3, doi:10.7554/eLife.00049 (2012).


  10. Xu, M., Chen, S. & Zhu, B. Investigating the cell cycle-associated dynamics of histone modifications using quantitative mass spectrometry. Methods Enzymol 512, 29-55, doi:10.1016/B978-0-12-391940-3.00002-0 (2012).


  11. Wen, Pei, Quan, Zhenghui & Xi, Rongwen*. The biological function of the WD40 repeat-containing protein p55/Caf1 in Drosophila. Dev Dyn 241, 455-464, doi:10.1002/dvdy.23730 (2012).


  12. Wei, Wei, Ba, Zhaoqing, Gao, Min, Wu, Yang, Ma, Yanting, Amiard, Simon, White, Charles I, Rendtlew Danielsen, Jannie Michaela, Yang, Yun-Gui & Qi, Yijun*. A role for small RNAs in DNA double-strand break repair. Cell 149, 101-112, doi:10.1016/j.cell.2012.03.002 (2012).


  13. Wang, Zhigao, Jiang, Hui, Chen, She, Du, Fenghe & Wang, Xiaodong*. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148, 228-243, doi:10.1016/j.cell.2011.11.030 (2012).


  14. Wang, Yixuan, Zheng, Chen-Guang, Jiang, Yonghua, Zhang, Jiqin, Chen, Jiayu, Yao, Chao, Zhao, Qingguo, Liu, Sheng, Chen, Ke, Du, Juan, Yang, Ze* & Gao, Shaorong*. Genetic correction of beta-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice. Cell Res 22, 637-648, doi:10.1038/cr.2012.23 (2012).


  15. Wang, Xiaoxue, Wu, Fangming, Xie, Qiguang, Wang, Huamei, Wang, Ying, Yue, Yanling, Gahura, Ondrej, Ma, Shuangshuang, Liu, Lei, Cao, Ying, Jiao, Yuling, Puta, Frantisek, McClung, C Robertson, Xu, Xiaodong & Ma, Ligeng*. SKIP is a component of the spliceosome linking alternative splicing and the circadian clock in Arabidopsis. Plant Cell 24, 3278-3295, doi:10.1105/tpc.112.100081 (2012).


  16. Sun, Liming, Wang, Huayi, Wang, Zhigao, He, Sudan, Chen, She, Liao, Daohong, Wang, Lai, Yan, Jiacong, Liu, Weilong, Lei, Xiaoguang* & Wang, Xiaodong*. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148, 213-227, doi:10.1016/j.cell.2011.11.031 (2012).


  17. Peng, S., Lin, X., Guo, Z. & Huang, N. Identifying multiple-target ligands via computational chemogenomics approaches. Curr. Top. Med. Chem. 12, 1363-1375, doi:10.2174/156802612801319016 (2012).


  18. Ma, Ming & Luo, Minmin*. Optogenetic activation of basal forebrain cholinergic neurons modulates neuronal excitability and sensory responses in the main olfactory bulb. J Neurosci 32, 10105-10116, doi:10.1523/JNEUROSCI.0058-12.2012 (2012).


  19. Liu, Tingting#, Liu, Zixu#, Song, Chuanjun, Hu, Yunfei, Han, Zhifu, She, Ji, Fan, Fangfang, Wang, Jiawei, Jin, Changwen, Chang, Junbiao*, Zhou, Jian-Min* & Chai, Jijie*. Chitin-induced dimerization activates a plant immune receptor. Science 336, 1160-1164, doi:10.1126/science.1218867 (2012).


  20. Liu, Bin#, Du, Hongwei#, Rutkowski, Rachael, Gartner, Anton & Wang, Xiaochen*. LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis. Science 337, 351-354, doi:10.1126/science.1220281 (2012).


  21. Lin, X., Huang, X. P., Chen, G., Whaley, R., Peng, S., Wang, Y., Zhang, G., Wang, S. X., Wang, S., Roth, B. L. & Huang, N. Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors. J Med Chem 55, 5749-5759, doi:10.1021/jm300338m (2012).


  22. Li, Peng, Li, Jun, Li, Ming, Dou, Kun, Zhang, Mei-Jun, Suo, Fang & Du, Li-Lin*. Multiple end joining mechanisms repair a chromosomal DNA break in fission yeast. DNA Repair (Amst) 11, 120-130, doi:10.1016/j.dnarep.2011.10.011 (2012).


  23. Li, Houhua, Wang, Xiaoming & Lei, Xiaoguang*. Total syntheses of Lycopodium alkaloids (+)-fawcettimine, (+)-fawcettidine, and (-)-8-deoxyserratinine. Angew Chem Int Ed Engl 51, 491-495, doi:10.1002/anie.201106753 (2012).


  24. Kong, Qing, Qu, Na, Gao, Minghui, Zhang, Zhibin, Ding, Xiaojun, Yang, Fan, Li, Yingzhong, Dong, Oliver X, Chen, She, Li, Xin & Zhang, Yuelin*. The MEKK1-MKK1/MKK2-MPK4 kinase cascade negatively regulates immunity mediated by a mitogen-activated protein kinase kinase kinase in Arabidopsis. Plant Cell 24, 2225-2236, doi:10.1105/tpc.112.097253 (2012).


  25. Kang, Lan & Gao, Shaorong*. Pluripotency of induced pluripotent stem cells. J Anim Sci Biotechnol 3, 5, doi:10.1186/2049-1891-3-5 (2012).


  26. Hu, Fei, Ren, Jing, Zhang, Ju-en, Zhong, Weixin & Luo, Minmin*. Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity. Proc Natl Acad Sci U S A 109, 17681-17686, doi:10.1073/pnas.1209185109 (2012).


  27. He, Jing, Kang, Lan, Wu, Tong, Zhang, Jiqin, Wang, Haitao, Gao, Haibo, Zhang, Yu, Huang, Bo, Liu, Wenqiang, Kou, Zhaohui, Zhang, Hongbing* & Gao, Shaorong*. An elaborate regulation of Mammalian target of rapamycin activity is required for somatic cell reprogramming induced by defined transcription factors. Stem Cells Dev 21, 2630-2641, doi:10.1089/scd.2012.0015 (2012).


  28. Gong, Yi-Nan & Shao, Feng*. Sensing bacterial infections by NAIP receptors in NLRC4 inflammasome activation. Protein Cell 3, 98-105, doi:10.1007/s13238-012-2028-3 (2012).


  29. Ge, Jianning, Gong, Yi-Nan, Xu, Ying & Shao, Feng*. Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking. Proc Natl Acad Sci U S A 109, 6193-6198, doi:10.1073/pnas.1117490109 (2012).


  30. Feng, Feng, Yang, Fan, Rong, Wei, Wu, Xiaogang, Zhang, Jie, Chen, She, He, Chaozu* & Zhou, Jian-Min*. A Xanthomonas uridine 5'-monophosphate transferase inhibits plant immune kinases. Nature 485, 114-118, doi:10.1038/nature10962 (2012).


  31. Fan, Di, Dai, Yan, Wang, Xuncheng, Wang, Zhenjie, He, Hang, Yang, Hongchun, Cao, Ying, Deng, Xing Wang & Ma, Ligeng*. IBM1, a JmjC domain-containing histone demethylase, is involved in the regulation of RNA-directed DNA methylation through the epigenetic control of RDR2 and DCL3 expression in Arabidopsis. Nucleic Acids Res 40, 8905-8916, doi:10.1093/nar/gks647 (2012).


  32. Dong, Na, Zhu, Yongqun*, Lu, Qiuhe, Hu, Liyan, Zheng, Yuqing & Shao, Feng*. Structurally distinct bacterial TBC-like GAPs link Arf GTPase to Rab1 inactivation to counteract host defenses. Cell 150, 1029-1041, doi:10.1016/j.cell.2012.06.050 (2012).


  33. Christofferson, Andrew J & Huang, Niu*. How to benchmark methods for structure-based virtual screening of large compound libraries. Methods Mol Biol 819, 187-195, doi:10.1007/978-1-61779-465-0_13 (2012).


  34. Cao, Ran, Liu, Minyu, Yin, Min, Liu, Quanhai, Wang, Yanli* & Huang, Niu*. Discovery of novel tubulin inhibitors via structure-based hierarchical virtual screening. J Chem Inf Model 52, 2730-2740, doi:10.1021/ci300302c (2012).



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