代谢组学中心

Metabolomics Center

北京生命科学研究所代谢组学中心实验室利用液质联用技术对分子量1500以下的小分子代谢物进行定性和定量分析，目前拥有Agilent 6495 QqQ和6540 QTOF质谱仪，为所内科研人员提供靶向代谢组学分析，脂质组学分析，非靶向代谢组学分析和基于质谱的化合物结构鉴定等服务。同时，代谢中心致力于开发引进新方法，增加代谢组学分析的灵敏性，准确性，和覆盖度，并希望将这些技术应用到生物基础研究中，为解决各种生命科学问题提供新思路。

The metabolomics center performs qualitative and quantitative analysis for metabolites and small molecules (typically with molecular weight of less than 1500 Da) using liquid chromatography–mass spectrometry (LC-MS). Currently the center is equipped with Agilent 6495 QqQ and 6540 QTOF instruments and we provide comprehensive metabolomics services including targeted metabolite assays, lipidomics analysis, untargeted metabolomic profiling, and MS-based compound identification. At the same time, we are introducing and developing new analytical methods to increase the sensitivity，accuracy and coverage of metabolomics. We hope to apply these techniques to the basic biological research and provide novel insights into various biological questions.

发表文章

Publications

1.   Liu Y, Zou W, Yang P, Wang L, Ma Y, Zhang H, Wang X: Autophagy-dependent ribosomal RNA degradation is essential for maintainingnucleotide homeostasis during C. elegans development. Elife 2018, 7. pii: e36588

2.   Kind T, Tsugawa H, Cajka T, Ma Y, Lai Z, Mehta S, Wohlgemuth G, Barupal D, Showalter M, Arita M: Identification of small molecules using accurate mass MS/MS search. Mass spectrometry reviews 2018, 37:513–532