董梦秋 博士

北京生命科学研究所高级研究员

Meng-Qiu Dong, Ph.D. Associate Investigator, NIBS, Beijing, China

Phone：010-80726688-8515

Fax： 010-80706053

E-mail：dongmengqiu@nibs.ac.cn

研究概述

Research Description

代表性文章

Representative Publications

1.      Li WJ^†, Wang CW^†, Tao L^†, Yan YH^†, Zhang MJ, Liu ZX, Li YX, Zhao HQ, Li XM, He XD, Xue Y*, Dong MQ*. (2021) Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans. Nat Commun. 12(1):4568.

2.      Jones AX^†, Cao Y^†, Tang YL^†, Wang JH, Ding YH, Tan H, Chen ZL, Fang RQ, Yin J, Chen RC, Zhu X, She Y, Huang N, Shao F, Ye K, Sun RX, He SM, Lei X*, Dong MQ*. (2019) Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers. Nat Commun. 10(1):3911.

3.      Chen ZL^†, Meng JM^†, Cao Y^†, Yin JL, Fang RQ, Fan SB, Liu C, Zeng WF, Ding YH, Tan D, Wu L, Zhou WJ, Chi H, Sun RX, Dong MQ*, He SM*. (2019) A high-speed search engine pLink with systematic evaluation for proteome-scale identification of cross-linked peptides. Nat Commun. 10(1):3404.

4.      Li ST^†, Zhao HQ^†, Zhang P^†, Liang CY, Zhang YP, Hsu AL, Dong MQ* (2019) DAF-16 stabilizes the aging transcriptome and is activated in mid-aged C. elegans to cope with internal stress. Aging Cell. 2019 Feb 17:e12896.

5.      Ding YH^†, Gong Z^†, Dong X^†, Liu K, Liu Z, Liu C, He SM, Dong MQ*, Tang C*. (2017) Modeling protein excited-state structures from "over-length" chemical cross-links. J Biol Chem. 292(4):1187-1196.

6.      Tan D^†, Li Q^†, Zhang MJ, Liu C, Ma C, Zhang P, Ding YH, Fan SB, Tao L, Yang B, Li X, Ma S, Liu J, Feng B, Liu X, Wang HW, He SM, Gao N, Ye K, Dong MQ*, Lei X*. (2016) Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. eLife. 2016 Mar 8;5. pii: e12509.

7.      Lu S^†, Fan SB^†, Yang B^†, Li YX, Meng JM, Wu L, Li P, Zhang K, Zhang MJ, Fu Y, Luo J, Sun RX, He SM*, and Dong MQ*. (2015) Mapping Native Disulfide Bonds at a Proteome Scale. Nature Methods 12(4):329-31.

8.      Shen EZ^†, Song CQ^†, Lin Y^†, Zhang WH, Su PF, Liu WY, Zhang P, Xu J, Lin N, Zhan C, Wang X, Shyr Y, Cheng H*, Dong MQ* (2014) Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans. Nature 508(7494): 128-132.

9.      Tao L, Xie Q, Ding YH, Li ST, Peng S, Zhang YP, Tan D, Yuan Z*, Dong MQ* (2013) CAMKII and Calcineurin Regulate the Lifespan of Caenorhabditis elegans through the FOXO Transcription Factor DAF-16. eLife 2:e00518.

10.   Yang B^†, Wu YJ^†, Zhu M^†, Fan SB^†, Lin J, Zhang K, Li S, Chi H, Li YX, Chen HF, Luo SK, Ding YH, Wang LH, Hao Z, Xiu LY, Chen S, Ye K, He SM*, and Dong MQ* (2012) Identification of Cross-linked Peptides from Complex Samples. Nature Methods 9(9): 904-906.