周俭民 博士

北京生命科学研究所资深研究员

Jianmin Zhou, Ph.D.

Investigator, NIBS, Beijing, China

其它学术兼职/服务

研究概述

Research Description

我们的主要研究兴趣是植物与病原微生物间相互作用的机理。植物可以感受病原菌的入侵，并且启动防卫反应成功地抵御病原菌的感染。而病原菌通过对寄主的适应，能够克服寄主的免疫反应，引发病害。

我们的工作主要以拟南芥和假单孢杆菌间互作为模式回答如下问题：植物是怎样感受病原菌并激活先天免疫反应的？其信号传导的分子机理是什么？病原菌的致病蛋白是如何克服植物免疫系统的？对这些问题的回答，有利于农业生产中对病害的控制。另外，因为动植物先天免疫机理的相似性和植物遗传易操作性，我们的工作还有助对动物先天免疫的认识。

The long term-interest of our laboratory concerns interactions between plants and pathogenic microbes. The research uses the Arabidopsis-Pseudomonas syringae model system to address the following fundamental questions. How do plants sense pathogens and activate innate immune responses? What are the molecular mechanisms underlying these processes? How do pathogen virulence proteins overcome host immunity?

部分发表文章

Selected Publications

1. Jie Zhang and Jian-Min Zhou (2010). Plant innate immunity triggered by microbial molecular signatures. Molecular Plant (invited review), in press.

2. Yujing Wang, Jifeng Li, Shuguo Hou, Xingwei Wang, Yuan Li, Dongtao Ren, She Chen, Xiaoyan Tang, and Jian-Min Zhou (2010). A Pseudomonas syringae ADP-Ribosyltransferase inhibits Arabidopsis Mitogen-Activated Protein Kinase Kinases. Plant Cell, 22, 2033-2044.

3. Jie Zhang, Haibin Lu, Xinyan Li, Yan Li, Haitao Cui, Chi-Kuang Wen, Xiaoyan Tang, Zhen Su, and Jian-Min Zhou. (2010). Effector-triggered and PAMP-triggered immunity differentially contribute to basal resistance to Pseudomonas syringae. MPMI, 23, 940-948.

4. Xin Deng, Lefu Lan, Yanmei Xiao, Megan Kennelly, Jian-Min Zhou, and Xiaoyan Tang (2010). Pseudomonas syringae two-component response regulator RhpR regulates promoters carrying an inverted repeat element. MPMI, 23, 927-939.

5. Jie Zhang, Wei Li, Tingting Xiang, Zixu Liu, Kristin Laluk, Xiaojun Ding, Yan Zou, Minghui Gao, Xiaojuan Zhang, She Chen, Tesfaye Mengiste, Yuelin Zhang, andJian-Min Zhou (2010). Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. Cell Host & Microbe, 7, 290-301.

6. Yan Li, QingQing Zhang, Jiangguang Zhang, Liang Wu, Yijun Qi, and Jian-Min Zhou (2010). Identification of miRNAs involved in Pathogen-Associated Molecular Pattern-triggered plant innate immunity. Plant Physiol., 152, 2222-231.

7. Haitao Cui, Yujing Wang, Li Xue, Jinfang Chu, Cunyu Yan , Jihong Fu, Mingsheng Chen, Roger W. Innes, and Jian-Min Zhou (2010). A Pseudomonas syringaeprotein perturbs Arabidopsis hormone signaling by activating MAP KINASE 4.Cell Host & Microbe, 7: 164-175.

8. Huamin Chen, Li Xue, Satya Chintamanani, Hugo Germain, Huiqiong Lin, Haitao Cui, Run Cai, Jianru Zuo, Xiaoyan Tang, Xin Li, Hongwei Guo, and Jian-Min Zhou (2009). ETHYLENE INSENSITIVE 3 and ETHYLENE INSENSITIVE 3-LIKE 1 repress SALICYLIC ACID INDUCTION DEFICIENT 2 expression to negatively regulate plant innate immunity. Plant Cell, 25, 2527-2540.

9. Haitao Cui, Tingting Xiang, and Jian-Min Zhou (2009). Plant immunity: A lesson from pathogenic bacterial effector proteins. Cellular Microbiology, 11, 1453-1461. (Invited review).

10. Huamin Chen, Yan Zou, Yulei Shang, Huiqiong Lin, Yujing Wang, Run Cai, Xiaoyan Tang, and Jian-Min Zhou (2008). Firefly luciferase complementation imaging assay for protein-protein interactions in plants. Plant Physiol. 146: 368-376.

11. Jian-Min Zhou and Jijie Chai (2008). Plant pathogenic bacterial type III effectors subdue host responses. Curr Opin Microbiol, 11, 179-185 (Invited review).

12. Tingting Xiang, Na Zong, Yan Zou, Yong Wu, Jie Zhang, Weiman Xing, Yan Li, Xiaoyan Tang, Lihuang Zhu, Jijie Chai, and Jian-Min Zhou (2008).Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases. Curr Biol, 18, 74-80.

13. Jie Zhang, Feng Shao, Yan Li, Haitao Cui, Linjie Chen, Hongtao Li, Yan Zou, Chengzu Long, Lefu Lan, Jijie Chai, She Chen, Xiaoyan Tang, and Jian-Min Zhou (2007). A Pseudomonas syringae Effector Inactivates MAPKs to Suppress PAMP-Induced Immunity. Cell Host & Microbe, 1,175-185.

14. Yulei Shang, Xinyan Li, Haitao Cui, Ping He, Roger Thilmony, Satya Chintamanani, Julie Zwiesler-Vollick, Suresh Gopalan, Xiaoyan Tang, and Jian-Min Zhou (2006). RAR1, a central player in plant immunity, is targeted byPseudomonas syringae effector AvrB. PNAS (track II), 103: 19200-19205.

15. Xiaoyan Tang and Jian-Min Zhou (2006). Regulation of the type III secretion system in phytopathogenic bacteria. MPMI, 19, 1159-1166. (review).

16. Xinyan Li, Huiqiong Lin, Weiguo Zhang, Yan Zou, Jie Zhang, Xiaoyan Tang, andJian-Min Zhou (2005). Flagellin induces innate immunity in nonhost interactions that is suppressed by Pseudomonas syringae effectors. PNAS(track II), 102: 12990-12995.

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