魏丽萍博士
- 基本信息
- 教育经历
- 工作经历
- 研究概述
- 发表文章
魏丽萍 博士
北京生命科学研究所资深研究员
Liping Wei, Ph.D. Investigator, NIBS, Beijing, China
Phone: 010-80726688-8610 010-80706016
Fax: 010-80706019 E-mail:weiliping@nibs.ac.cn
教育经历
Education
2000年 |
美国斯坦福大学医学院医学信息学专业(现更名为生物医学信息学)博士 |
Ph.D., Medical Information Sciences(now renamed Biomedical Informatics), Stanford University School of Medicine, Stanford, California, USA |
|
1994年 |
美国布朗大学应用数学系硕士 |
M.Sc., Applied Mathematics, Brown University, Providence, Rhode Island, USA |
|
1993年 |
中国科学技术大学无线电电子学系(现更名为电子工程与信息科学系)本科 |
Undergraduate, Radio Electronics (now renamed Electrical Engineering and Information Sciences), University of Science and Technology of China, Hefei, Anhui, China |
工作经历
Professional Experience
2011年- |
北京生命科学研究所资深研究员 |
Investigator, National Institute of Biological Sciences, Beijing, China |
|
2004年- |
北京大学生物信息学中心教授、主任;蛋白质工程及植物基因工程国家重点实验室副主任 |
Professor, Director, Center for Bioinformatics, Peking University; Associate Director, National Laboratory of Protein Engineering and Plant Genetic Engineering, Beijing, China |
|
2002-2004年 |
美国斯坦福大学医学院医学信息学专业兼职助理教授 |
Consulting Assistant Professor of Medicine (Biomedical Informatics), Stanford University School of Medicine, Stanford, California, USA |
|
2001-2003年 |
美国Nexus Genomics公司共同创始人兼首席科学家 |
Co-founder, Chief Scientific Officer, Nexus Genomics, Inc., Mountain View, California, USA |
学术服务及获奖
Professional Services and Honors
2010-2013
Member of the Board of Directors, International Society of Computational Biology (ISCB)
(selected by worldwide election by members of ISCB, the largest international society for bioinformatics and computational biology with members in over 70 countries.)
2009-
Member of the Public Library of Science (PLoS) International Advisor Group
2010
国家杰出青年科学基金
2010
中国青年科技奖
2012
青年女科学家奖(China Young Woman Scientist Fellowship)
研究概述
Research Description
本实验室的长远目标是找到更好治疗包括自闭症及其并发疾病在内的儿童神经精神疾病的新方法。我们致力于探索人类行为与情感的生物学基础,力求从根本上帮助患儿及其家庭。在下面五年里,我们首先着重研究自闭症的遗传机制及癫痫的药物基因组学规律。我们正在建立一个包括病例-对照、家系、及双胞胎在内的大规模儿童神经精神疾病样本库,并采用以下策略在全基因组水平研究表型与基因型的关联:
(1)通过对病人详细的表型分析,寻找极端亚型及新疾病类型;
(2)利用新一代测序技术,对病人进行全基因组或全外显子组测序;
(3)充分发挥本实验室的生物信息学技术,对儿童神经精神疾病进行系统的整合分析。
为促进长期研究,本实验室实现高度电子化,将所有病人病历、样本跟踪、个体基因组测序结果、及后续生物信息学分析整合于一个以MySQL关系型数据库为基础,以人类基因组为框架的生物医学信息平台。
部分发表文章
Select Publications
1. Zhou WZ, Ye AY, Sun Z, Tian HH, Pu TZ, Wu YY, Wang DD, Zhao M, Lu SJ, Yang CH, Wei L., Statistical analysis of twenty years (1993-2012) of data from mainland China’s first intervention center for children with Autism Spectrum Disorder. Molecular Autism. 2014, 5:52.
2. Zhao HQ, Zhang P, Gao H, He X, Dou Y, Huang AY, Liu X, Ye AY, Dong MQ, Wei L. Profiling the RNA editomes of wild-type C. elegans and ADAR mutants. Genome Res. 2014 Nov 4. pii: gr.176107.114. [Epub ahead of print]
3. Iossifov I, et al, The contribution of de novo coding mutations to autism spectrum disorder, Nature. 2014 Nov 13;515(7526):216-21. doi: 10.1038/nature13908. Epub 2014 Oct 29.
4. Ding Y, et al, Wei L. "Bioinformatics: Introduction and Methods", a bilingual Massive Open Online Course (MOOC) as a new example for global bioinformatics education. PLoS Computational Biology, 2014, in press
5. Dong S, Walker MF, Carriero NJ, DiCola M, Willsey AJ, Ye AY, Waqar Z, Gonzalez LE, Overton JD, Frahm S, Keaney JF 3rd, Teran NA, Dea J, Mandell JD, Hus Bal V, Sullivan CA, DiLullo NM, Khalil RO, Gockley J, Yuksel Z, Sertel SM, Ercan-Sencicek AG, Gupta AR, Mane SM, Sheldon M, Brooks AI, Roeder K, Devlin B, State MW, Wei L, Sanders SJ.. De novo insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder. Cell Rep. 2014 Oct 9;9(1):16-23. doi: 10.1016/j.celrep.2014.08.068. Epub 2014 Oct 2.
6. Huang YA, Xu X, Ye AY, Wu Q, Yan L, Zhao B, Yang X, He Y, Wang S, Zhang Z, Gu B, Zhao HQ, Wang M, Gao H, Gao G, Zhang Z, Yang X, Wu X, Zhang Y, Wei L. Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals. Cell Res. 2014 Nov;24(11):1311-27. doi: 10.1038/cr.2014.131. Epub 2014 Oct 14.
7. Yang X, Gao H, Zhang J, Xu X, Liu X, Wu X, Wei L, Zhang Y. ATP1A3 Mutations and Genotype-Phenotype Correlation of Alternating Hemiplegia of Childhood in Chinese Patients. PLoS One. 2014 May 19;9(5):e97274
8. Gao G, Vibranovski MD, Zhang L, Li Z, Liu M, Zhang YE, Li X, Zhang W, Fan Q, VanKuren NW, Long M, Wei L. A long term demasculinization of X-linked intergenic noncoding RNAs in Drosophila melanogaster. Genome Res. 2014. Apr;24(4):629-38.
9. Willsey AJ, et.al., Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. Cell. 2013 Nov 21;155(5):997-1007. doi: 10.1016/j.cell.2013.10.020.
10. Huang Y, Xie C, Ye AY, Li CY, Gao G, Wei L. Recent adaptive events in human brain revealed by meta-analysis of positively selected genes. PLoS One. 2013 Apr 9;8(4):e61280.
11. Xie C, Zhang YE, Chen JY, Liu CJ, Zhou WZ, Li Y, Zhang M, Zhang R, Wei L, and Li CY. Hominoid-specific de novo protein-coding genes originating from long non-coding RNAs. PLoS Genet. 2012 Sep;8(9):e1002942.
12. Xu LM, Li JR, Huang Y, Zhao M, Tang X, Wei L. AutismKB: an evidence-based knowledgebase of autism genetics. Nucleic Acids Res. 2012 Jan;40(Database issue):D1016-22
13. Li CY, Zhang Y, Wang Z, Zhang Y, Cao C, Zhang PW, Lu SJ, Li XM, Yu Q, Zheng X, Du Q, Uhl GR, Liu QR, Wei L. A human-specific de novo protein-coding gene associated with human brain functions. PLoS Comput Biol. 2010 Mar 26;6(3):e1000734.
14. Zhang Y, Lu S, Zhao S, Zheng X, Long M, Wei L. Positive selection for the male functionality of a co-retroposed gene in the hominoids, BMC Evolutionary Biology. 2009. 9, 252
15. Gao G, Li JT, Kong L, Tao L, Wei L, Human herpesvirus miRNAs statistically preferentially target host genes involved in cell signaling and adhesion/junction pathways. Cell Research. 2009 May;19(5):665-7
16. Li JT, Zhang Y, Kong L, Liu QR, Wei L., Trans-natural antisense transcripts including noncoding RNAs in 10 species: implications for expression regulation. Nucleic Acids Res. 2008 Sep;36(15):4833-44
17. Li CY, Mao X, Wei L, Genes and (Common) Pathways Underlying Drug Addiction, Plos Computational Biology, 2008, Jan 4;4(1):e2. (This work was featured by Science Signaling, the Economist, Reuters, and ~100 other scientific and public media.)
18. Kong L, Zhang Y, Ye ZQ, Liu XQ, Zhao SQ, Wei L, Gao G. CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine. Nucleic Acids Res. 2007 Jul 1;35:W345-9.
19. Ye ZQ, Zhao SQ, Gao G, Liu XQ, Langlois RE, Lu H, Wei L. Finding new structural and sequence attributes to predict possible disease association of single amino acid polymorphism (SAP). Bioinformatics. 2007 Jun 15;23(12):1444-50.
20. Li CY, Yu Q, Ye ZQ, Sun Y, He Q, Li XM, Zhang W, Luo J, Gu X, Zheng X, Wei L. A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir. Cell Res. 2007 Apr;17(4):357-62. (Cover story and featured by a Research Highlight. Highlighted by FDA annual Pediatric Safety Update for Tamiflu.)
21. Cai Z, Mao X, Li S, Wei L. Genome comparison using Gene Ontology (GO) with statistical testing, BMC Bioinformatics 2006, 7:374.
22. Shi YH, Zhu SW, Feng JX, Mao X, Zhang L, Cheng J, Wei L, Wang ZY, Zhu YX, “Transcriptome Profiling, Molecular Biological and Physiological Studies Revealed a Major Role of Ethylene in Cotton Fiber Cell Elongation”,Plant Cell, 2006 Mar;18(3):651-64.
23. Mao X., Cai T., Olyarchuk J.G., Wei L., “Automated Genome Annotation and Pathway Identification Using the KEGG Orthology (KO) As a Controlled Vocabulary”, Bioinformatics, 21(19): 3787–93, 2005
应邀综述
Invited Reviews
1. Wei L, Yu J. Bioinformatics in china: a personal perspective. PLoS Comput Biol. 2008 Apr 25;4(4):e1000020
2. Wei L, Liu Y, Dubchak I, Shon JCY, and Park JY, “Comparative Genomics Approaches to Study Organism Similarities and Differences.” Journal of Biomedical Informatics, 35:142-150, 2002.
专利
Patent
魏丽萍、李川昀、叶志强、贺权源、于泉、张武学、孙颖、罗静初、顾孝诚、郑晓峰, “一种预测达菲类药物用药安全性的方法”. 专利号ZL 200610011569.3. 专利申请日:2006-3-28. 授权公告日:2008-3-26.
Wei L, Li CY, Ye ZQ, He QY, Yu Q, Zhang WX, Sun Y, Luo J, Gu XC, Zheng XF, Chinese patent “A method to predict the safety of administering Oseltamivir Phosphate”. Patent Number: ZL 200610011569.3. Priority Date: March 28, 2006. Issued: March 26, 2008.