占成，北京生命科学研究所 影像中心主任， 副研究员

Email: zhancheng@nibs.ac.cn

电话： 010-80726688-8870

传真： 010-80724500

Room Number： B058

教育背景

2011   博士，生物医学工程，华中科技大学

2006   硕士，生物医学工程，华中科技大学

工作经历

2011-至今    影像中心主任，副研究员，北京生命科学研究所

2006-2008 工程师，北京生命科学研究所

研究概述

NIBS影像中心为研究所各实验室提供生物光学成像服务，中心现有多套高级光学显微成像系统，包括激光点扫描共聚焦显微镜，转盘式共聚焦显微镜，双光子显微镜，以及玻片扫描显微镜，可以对固定切片、培养细胞和活体动植物细胞等多种生物样品进行光学成像实验。在提供服务的同时，影像中心也致力于开发一些新的光学成像技术和方法，解决一些具体的实验技术难题，取得了一系列成果（PNAS 2018, Dev Cell 2018, Oncotarget 2015, Nature 2014）。

另一方面，我们还独立开展神经生物学方面的研究，尤其对大脑如何调控机体的能量代谢感兴趣。大脑通过自主神经系统和神经内分泌系统调控机体各个器官的活动，实现对生理功能与行为的控制。过去和未来的几年中，我们围绕着大脑与外周器官如何相互作用实现代谢控制这一关键问题，从摄食调控（JNS 2013， Frontiers in neuroanatomy 2015）、血糖调控(Neuron 2018)，以及体温调控等多个方面入手，运用多种技术手段解析大脑调控代谢的神经机制与物质基础。

发表文章

1、L. Mei, Y.Fan , M. Wang, X. Lv , C. Zhan#, E. Zhang#. Longitudinal in vivo recording of clock gene transcription in the brains of freely-moving mice. PNAS (2018). #co-corresponding author.

2、L. Mei , C. Zhan , E. Zhang. In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters. JOVE (2018).

3、Z. Zhao, L. Wang, W. Gao, F. Hu, J. Zhang, Y. Ren, R. Lin, Q. Feng, M. Cheng, D. Ju, Q. Chi, D. Wang, S. Song, M. Luo and C. Zhan# (2017). A Central Catecholaminergic Circuit Controls Blood Glucose Levels during Stress. Neuron 95, 138-152 e135. Featured Article. # corresponding author.

4、D. Wang, X. He, Z. Zhao, Q.Feng, R.Lin, Y. Sun, T. Ding, F. Xu #, M. Luo #, C. Zhan # (2015) Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons. Frontiers in Neuroanatomy 9:40. # co-corresponding author.

5、C. Zhan*#, J. Zhou *, Q. Feng, J. Zhang, S. Lin, J. Bao, P. Wu, M. Luo #, Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively. J Neurosci 33:3624-3632, 2013. Selected for F1000Prime. # co-correspondence author, *co-fist author, co-corresponding author.
6、C. Zhan, M. Luo, Diverse patterns of odor representation by neurons in the anterior piriform cortex of awake mice. J Neurosci 30, 16662-16672, 2010.

7、S. Zeng, X. Lv, C. Zhan, W. R. Chen, et al. Simultaneous compensation for spatial and temporal dispersion of acousto-optical deflectors for two-dimensional scanning with a single prism. Optics Letters, 2006, 31(8): 1091-1093.

8、 Shen, E.Z., Song, C.Q., Lin, Y., Zhang, W.H., Su, P.F., Liu, W.Y., Zhang, P., Xu, J., Lin, N., Zhan, C., Wang, X., Shyr, Y., Cheng, H., and Dong, M.Q. Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans. Nature 508, 128-132.

9、Tang, Z., Hu, Y., Wang, Z., Jiang, K., Zhan, C., Marshall, W.F., and Tang, N. (2018). Mechanical Forces Program the Orientation of Cell Division during Airway Tube Morphogenesis. Dev Cell

10、Mengxiao Yu, Fuyou Li, Zhigang Chen, He Hu, C. Zhan, Hong Yang and Chunhui Huang, Laser Scanning Up-Conversion Luminescence Microscopy for Imaging Cells Labeled with Rare-Earth Nanophosphors, Anal. Chem. 2009, 81(3), 930–935.

11、H. Zhang, C. Zhan, J. Ke, Z. Xue, A. Zhang, K. Xu, Z. Shen, L. Yu, L. Chen, EGFR Kinase domain mutation positive lung cancers are sensitive to intrapleural perfusion with hyperthermic chemotherapy (IPHC) complete treatment, Oncotarget, DOI: 10.18632/oncotarget.6491. Dec. 8, 2015.

12、X. Lv, C. Zhan, S. Zeng, W. R. Chen, et al. Construction of multiphoton laser scanning microscope based on dual-axis acousto-optic deflector. Review of Scientific Instruments, 2006, 77(4).

13、Shaoqun Zeng, Xiaohua Lv, Kun Bi, C. Zhan, et al. Analysis of the dispersion compensation of acousto-optic deflectors used for multiphoton imaging. Journal of Biomedical Optics, 2007, 12(2).

书籍章节

Zhan C. POMC Neurons: Feeding, Energy Metabolism, and Beyond. In Neural Regulation of Metabolism. 2018 (pp. 17-29). Springer, Singapore.

国际专利

Shaoqun Zeng, Qingming Luo, C. Zhan, Xiaohua Lv. LIGHT PULSE POSITIONING WITH DISPERSION COMPENSATION. United States Patent, Patent No: US 7,821,698 B2, Published on Oct.26, 2010