核酸测序中心

蔡涛博士

核酸测序中心主任

电话：010-80726688-8880

Room Number: B027

E-mail: caitao@nibs.ac.cn

教育经历

Education

2006年 北京大学生物信息学博士

Ph.D.  Bioinformatics, Peking University, China

2001年 北京大学生理学及生物物理学学士

B.S.  Physiology & Biophysics, Peking University，China

工作经历

Professional Experience

2010年- 北京生命科学研究所测序中心主任

Director, Sequencing Center, National Institute of Biological Sciences, Beijing, China

2008-2010年 博士后， 洛桑中心医院，瑞士

Postdoctoral Researcher, Lausanne University Hospital (CHUV), Switzerland

2006-2008年 博士后，北京生命科学研究所

Postdoctoral Researcher, National Institute of Biological Sciences, Beijing, China

研究概述

Research Description

测序技术近些年有着飞速的发展，通过高通量测序技术可以获得单细胞分辨率的基因组，转录组以及表观遗传学信息，测序技术在基础科研以及转化医学研究中被广为应用。我们实验室拥有一流的测序设备，我们致力开发相关测序技术以及测序数据分析方法，探索使用测序技术来解决生物学及临床医学问题。

Sequencing technology is widely used in basic researches and translational studies. The state-of-the-art sequencing technology can provide great amount of information for the composition, variation, interaction, regulation and modification of DNA or RNA. Our lab is equipped with the advanced next-generation sequencing (NGS) platform, single cell library preparation system and high performance computation system. Our research focuses on developing new NGS technology, exploring new NGS application and understanding huge mass of sequencing data.

代表性论文：

1.      Wang Y.; Tang Z.; Huang H.; Li J.; Wang Z.; Yu Y.; Zhang C.; Dai H.; Wang F.; Cai T.*, and Tang N.*, Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate. Proc Natl Acad Sci U S A, 2018. * co-corresponding authors

2.      Gao Y, Chen J, Li K, Wu T, Huang B, Liu W, Kou X, Zhang Y, Huang H, Jiang Y, Yao C, Liu X, Lu Z, Xu Z, Kang L, Chen J, Wang H, Cai T*, and Gao S*. Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation and Hydroxymethylation in Reprogramming. Cell Stem Cell, doi.org/10.1016/j.stem.2013.02.005, Mar.14, 2013 *co-corresponding authors

3. Cai T, J.F. Dufour, B. Muellhaupt, T. Gerlach, M. Heim, D. Moradpour, A. Cerny, R. Malinverni, V. Kaddai, M. Bochud, et al., Viral Genotype-Specific Role of PNPLA3, PPARG, MTTP and IL28B in Hepatitis C Virus-Associated Steatosis. J Hepatol, 2011.

4.      Rauch, A.*, Z. Kutalik*, P. Descombes*, Cai T, J. Di Iulio, T. Mueller, M. Bochud, M. Battegay, E. Bernasconi, J. Borovicka, et al., Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study. Gastroenterology, 2010. 138(4): p. 1338-45, 1345 e1-7.

5.      Mi, S.*, Cai T*, Y. Hu, Y. Chen, E. Hodges, F. Ni, L. Wu, S. Li, H. Zhou, C. Long, et al., Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell, 2008. 133(1): p. 116-27. * co-first authors